HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome
نویسندگان
چکیده
منابع مشابه
HERV-K HML-2 diversity among humans.
Retroviruses comprise over 8% of the human genome (1, 2). Human endogenous retroviruses (HERVs) exist as DNA remnants of infections that occurred in germ lineage cells of our ancestors. Most of this viral DNA is mutated, often including various large disruptions, but some components are intact or otherwise functional. What viral components exist in human genomes, and what gene products do they ...
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Recent studies suggested a role for the human endogenous retrovirus (HERV) group HERV-K(HML-2) in melanoma because of upregulated transcription and expression of HERV-K(HML-2)-encoded proteins. Very little is known about which HML-2 loci are transcribed in melanoma. We assigned >1,400 HML-2 cDNA sequences generated from various melanoma and related samples to genomic HML-2 loci, identifying a t...
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In the presented assay, we elaborated a method for distinguishing sequences that are genetically closely related to each other. This is particularly important in a situation where a fine balance of the allele abundance is a point of research interest. We developed a peptide nucleic acid (PNA) strand invasion technique for the differentiation between multiple sclerosis-associated retrovirus (MSR...
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HERV-K is a 50-copy, human endogenous, class 1 retroviral element that contains some polycistrons with gag, pol, and env open reading frames. Although expression of HERV-K proviruses has been shown in cultured human cell lines, expression of these elements has not been shown in human blood leukocytes. Using both reverse transcriptase-polymerase chain reaction and ribonuclease protection techniq...
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ژورنال
عنوان ژورنال: Autoimmunity Highlights
سال: 2019
ISSN: 2038-0305,2038-3274
DOI: 10.1186/s13317-019-0122-8